Article

Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome

2022-04-02

Abstract excerpt

The PD-1 inhibitor pembrolizumab is effective in treating Sézary syndrome, a leukemic variant of cutaneous T-cell lymphoma. Our purpose was to investigate the effects of pembrolizumab on healthy and malignant T cells in Sézary syndrome and to discover characteristics that predict pembrolizumab response. Samples were analyzed before and after 3 weeks of pembrolizumab treatment by single-cell RNA-sequencing of 118,9...

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Literature Corpus work: 72ed597c-620d-5d11-95ed-6fbfcb672bcf
DOI: 10.1101/2022.03.29.22272994

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