Article
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
Nature genetics - 1 Dec 2015
da Silva Almeida Ana Carolina, Abate Francesco, Khiabanian Hossein, Martinez-Escala Estela, Guitart Joan, Tensen Cornelis P, Vermeer Maarten H, Rabadan Raul, Ferrando Adolfo, Palomero Teresa
Abstract excerpt
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells. Here we performed whole-exome sequencing of tumor-normal sample pairs from 25 patients with Sézary syndrome and 17 patients with other CTCLs. These analyses identified a distinctive pattern of somatic copy number alterations in Sézary...
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