Single-cell RNA sequencing comparison of CD4+, CD8+ and T-cell receptor γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes.

doi:10.1093/bjd/ljae313

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Article

Single-cell RNA sequencing comparison of CD4+, CD8+ and T-cell receptor γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes.

The British journal of dermatology - 24 Jan 2025

Chennareddy Sumanth, Rindler Katharina, Ruggiero John R, Alkon Natalia, Cohenour Emry R, Tran Sophia, Weninger Wolfgang, Griss Johannes, Jonak Constanze, Brunner Patrick M

Abstract excerpt

BACKGROUND: Malignant clones of primary cutaneous T-cell lymphomas (CTCL) can show a CD4+, CD8+ or T-cell receptor (TCR)-γδ+ phenotype, but their individual impact on tumour biology and skin lesion formation remains ill defined. OBJECTIVES: To perform a comprehensive molecular characterization of CD4+ vs. CD8+ and TCR-γδ+ CTCL lesions. METHODS: We performed single-cell RNA sequencing (scRNAseq) of 18 CTCL skin...

Topics

Humans
Skin Neoplasms
Lymphoma, T-Cell, Cutaneous
Receptors, Antigen, T-Cell, gamma-delta
Male
Single-Cell Analysis
Female
CD4-Positive T-Lymphocytes
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

CD8-Positive T-Lymphocytes

Aged

Skin

Adult

Sequence Analysis, RNA

Mycosis Fungoides

Source

Open in PubMed Open full text

Identifiers

PMID: 39133553
DOI: 10.1093/bjd/ljae313
PMCID: PMC11758594

Genes

CD4
CCR7
CD69
CTSW
CXCR4
GZMA
GZMM
KRT16
NKG7
NR4A1
SELL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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