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Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome

27 Aug 2022

Abstract excerpt

The PD-1 inhibitor pembrolizumab is effective in treating Sézary syndrome, a leukemic variant of cutaneous T-cell lymphoma. Our purpose was to investigate the effects of pembrolizumab on healthy and malignant T cells in Sézary syndrome and to discover characteristics that predict pembrolizumab response. Samples were analyzed before and after 3 weeks of pembrolizumab treatment using single-cell RNA-sequencing of...

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PMID: 36046812
DOI: 10.1080/2162402x.2022.2115197

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