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Article

NUP98::NSD1 and FLT3/ITD co-expression is an independent predictor of poor prognosis in pediatric AML patients.

BMC pediatrics - 24 Aug 2024

Wang Jing-Wen, Yu-Li, Yang Xing-Ge, Xu Lu-Hong

Abstract excerpt

OBJECTIVE: Patients who carry NUP98::NSD1 or FLT3/ITD mutations are reported to have poor prognosis. Previous studies have confidently reported that the poor outcome in younger AML patients is owning to dual NUP98::NSD1 and FLT3/ITD positivity, with a high overlap for those two genetic lesions. In this study, we assessed the prognostic value of the presence of both NUP98::NSD1 and FLT3/ITD in pediatric AML...

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PMID: 39182032
DOI: 10.1186/s12887-024-05007-3
PMCID: PMC11344362

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