Clinical implications of NUP98::NSD1 fusion at diagnosis in adult FLT3-ITD positive AML.

doi:10.1111/ejh.14055

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Article

Clinical implications of NUP98::NSD1 fusion at diagnosis in adult FLT3-ITD positive AML.

European journal of haematology - 1 Oct 2023

Miyajima Toru, Onozawa Masahiro, Yoshida Shota, Miyashita Naoki, Kimura Hiroyuki, Takahashi Shogo, Yokoyama Shota, Matsukawa Toshihiro, Goto Hideki, Sugita Junichi, Fujisawa Shinichi, Hidaka Daisuke, Ogasawara Reiki, Mori Akio, Matsuoka Satomi, Shigematsu Akio, Wakasa Kentaro, Kasahara Ikumi, Saga Tomoyuki, Hashiguchi Junichi, Takeda Yukari, Ibata Makoto, Yutaka Tsutsumi, Fujimoto Katsuya, Kondo Takeshi, Teshima Takanori

Abstract excerpt

OBJECTIVES: The cryptic fusion oncogene NUP98::NSD1 is known to be associated with FLT3-ITD mutation in acute myeloid leukemia (AML), and an independent poor prognostic factor in pediatric AML. However, there are little data regarding the clinical significance of NUP98::NSD1 in adult cohort. METHODS: We conducted a multicenter retrospective study to investigate the prevalence, clinical characteristics, and...

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PMID: 37465857
DOI: 10.1111/ejh.14055

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