Article

Formin-mediated nuclear actin assembly at androgen receptors promotes transcriptional droplet formation

2023-01-31

Abstract excerpt

<title>Abstract</title> <p>Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor (AR) binds androgens mediating gene expression for sexual, somatic, and behavioral functions, and is involved in various conditions including androgen-insensitivity-syndrome (AIS) or prostate cancer. Here we identified functional AIS-patient mutations in the formi...

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Literature Corpus work: 0713e689-5690-5053-acfa-4b256151291a
DOI: 10.21203/rs.3.rs-1664650/v1

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