Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003

Loy C J, Sim K S, Yong E L

Abstract excerpt

The androgen receptor (AR), a nuclear transcription factor, mediates male sexual differentiation, and its excessive action is associated with prostate cancer. We have characterized a negative regulatory domain in the AR hinge region, which interacted with filamin A (FLNa), an actin-binding cytosk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Contractile Proteins
Share to Filamins
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Peptide Fragments

Share to Receptors, Androgen

Share to Transcriptional Activation

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 12682292
DOI: 10.1073/pnas.0736237100
PMCID: PMC153595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12682292-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.PMID 12682292Read ↗

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells.Semantic proximity Read ↗

Androgen-Induced Cell Migration: Role of Androgen Receptor/Filamin A AssociationSemantic proximity Read ↗

Regulation of the Transcriptional Coactivator FHL2 Licenses Activation of the Androgen Receptor in Castrate-Resistant Prostate CancerSemantic proximity Read ↗

The function and pathogenic mechanism of filamin A.Semantic proximity Read ↗

Nuclear versus Cytoplasmic Localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with MetastasesSemantic proximity Read ↗

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein FilaminSemantic proximity Read ↗

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein FilaminSemantic proximity Read ↗

FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFRSemantic proximity Read ↗

Role of actin-binding proteins in prostate cancerSemantic proximity Read ↗

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 CellsSemantic proximity Read ↗

Extranuclear partners of androgen receptor: at the crossroads of proliferation, migration, and neuritogenesisSemantic proximity Read ↗

The filamins: organizers of cell structure and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.