Article
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
The Lancet. Oncology - 1 Aug 2017
Turajlic Samra, Litchfield Kevin, Xu Hang, Rosenthal Rachel, McGranahan Nicholas, Reading James L, Wong Yien Ning S, Rowan Andrew, Kanu Nnennaya, Al Bakir Maise, Chambers Tim, Salgado Roberto, Savas Peter, Loi Sherene, Birkbak Nicolai J, Sansregret Laurent, Gore Martin, Larkin James, Quezada Sergio A, Swanton Charles
Abstract excerpt
BACKGROUND: The focus of tumour-specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of small insertions and deletions (indels) less well characterised. We investigated whether the frameshift nature of indel mutations, which create novel open reading frames and a large quantity of mutagenic peptides highly distinct from self, might contribute to the immunogenic phenotype....
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