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Dendrimer-tesaglitazar conjugate induces a phenotype shift of microglia and enhances β-amyloid phagocytosis.

Nanoscale - 21 Jan 2021

DeRidder Louis, Sharma Anjali, Liaw Kevin, Sharma Rishi, John John, Kannan Sujatha, Kannan Rangaramanujam M

Abstract excerpt

Switching microglia from a disease exacerbating, 'pro-inflammatory' state into a neuroprotective, 'anti-inflammatory' phenotype is a promising strategy for addressing multiple neurodegenerative diseases. Pro-inflammatory microglia contribute to disease progression by releasing neurotoxic substances and accelerating pathogenic protein accumulation. PPARα and PPARγ agonists have both been shown to shift microglia...

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PMID: 33479718
DOI: 10.1039/d0nr05958g

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