Article

Beta cells are essential drivers of pancreatic ductal adenocarcinoma development

2024-12-03

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic endocrine-exocrine crosstalk plays a key role in normal physiology and disease. For instance, endocrine islet beta (β) cell secretion of insulin or cholecystokinin (CCK) promotes progression of pancreatic adenocarcinoma (PDAC), an exocrine cell-derived tumor. However, the cellular and molecular mechanisms that govern endocrine-exocrine signaling in tumorigenesis remain incompletely und...

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Literature Corpus work: 4507d2e1-b87d-5b07-9fb5-6a292eb7b5ed
DOI: 10.1101/2024.11.29.626079

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