Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2014

Maltese Marta, Martella Giuseppina, Madeo Graziella, Fagiolo Irene, Tassone Annalisa, Ponterio Giulia, Sciamanna Giuseppe, Burbaud Pierre, Conn P Jeffrey, Bonsi Paola, Pisani Antonio

Abstract excerpt

Broad-spectrum muscarinic receptor antagonists have represented the first available treatment for different movement disorders such as dystonia. However, the specificity of these drugs and their mechanism of action is not entirely clear. We performed a systematic analysis of the effects of anticholinergic drugs on short- and long-term plasticity recorded from striatal medium spiny neurons from DYT1 dystonia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysics
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Stimulation

Share to Excitatory Postsynaptic Potentials

Share to Long-Term Potentiation

Share to Patch-Clamp Techniques

Share to Synapses

Share to Thalamus

Source

Open in PubMed Open full text

Identifiers

PMID: 25195914
DOI: 10.1002/mds.26009
PMCID: PMC4216601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.PMID 25195914Read ↗

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia.Semantic proximity Read ↗

Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.Semantic proximity Read ↗

Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.Semantic proximity Read ↗

Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia.Semantic proximity Read ↗

Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dtsz) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.Semantic proximity Read ↗

Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA.Semantic proximity Read ↗

A Novel Transgenic Mouse Model to Investigate the Cell-Autonomous Effects of torsinA(ΔE) Expression in Striatal Output Neurons.Semantic proximity Read ↗

Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatumSemantic proximity Read ↗

Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of TOR1A dystonia.Semantic proximity Read ↗

A new knock-in mouse model of l-DOPA-responsive dystonia.Semantic proximity Read ↗

The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.Semantic proximity Read ↗

Abnormal plasticity in dystonia: Disruption of synaptic homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.