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Article

Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications.

Annual review of pharmacology and toxicology - 1 Jan 2004

Wess Jürgen

Abstract excerpt

Muscarinic acetylcholine receptors (mAChRs; M1-M5) play key roles in regulating the activity of many important functions of the central and peripheral nervous system. Because of the lack of ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more mAChR subtypes, identification of the physiological and pathophysiological roles of the...

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PMID: 14744253
DOI: 10.1146/annurev.pharmtox.44.101802.121622

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