Article
M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.
Journal of molecular neuroscience : MN - 1 Jan 2006
Gautam Dinesh, Duttaroy Alokesh, Cui Yinghong, Han Sung-Jun, Deng Chuxia, Seeger Thomas, Alzheimer Christian, Wess Jürgen
Abstract excerpt
The five muscarinic acetylcholine receptors (M1-M5 mAChRs) mediate a very large number of important physiological functions (Caulfield, 1993; Caulfield and Birdsall, 1998; Wess, 2004). Because of the lack of small molecule ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more mAChR subtypes, identification of the physiological and...
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