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Article

Clonal Hematopoiesis of Indeterminate Potential Associated with Covert Cerebral Changes.

Annals of neurology - 1 Oct 2025

Li Yijuan, Zhang Dingding, Han Fei, Zhou Lixin, Ni Jun, Yao Ming, Jin Zhengyu, Zhang Shuyang, Cui Liying, Yang Xinzhuang, Zhu Yi-Cheng

Abstract excerpt

OBJECTIVE: Clonal hematopoiesis of indeterminate potential (CHIP) is an emerging risk factor for cardio-cerebrovascular diseases. This study aimed to investigate CHIP's association with cerebrovascular or glymphatic changes in a community-based population. METHODS: This study examined Chinese community cohort participants. CHIP mutations were identified through whole-exome sequencing. Intracranial arterial...

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PMID: 40575838
DOI: 10.1002/ana.27304

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