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Comparative analysis of replication and immune evasion among SARS-CoV-2 subvariants BA.2.86, JN.1, KP.2, and KP.3.

mBio - 11 Jun 2025

Hu Yanping, Zou Jing, Nguyen Michael D, Chang Hope C, Yeung Jason, Hao Haiping, Shi Pei-Yong, Ren Ping, Xie Xuping

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2.86 sublineage and its descendants (JN.1, KP.2, and KP.3) have acquired key recurrent mutations (R346T, L455S, F456L, and Q493E) and became predominant strains, following the epidemiological progression: BA.2.86→JN.1→KP.2→KP.3. However, the mechanisms driving this succession remain incompletely understood. In this study, we assessed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40298448
DOI: 10.1128/mbio.03503-24
PMCID: PMC12153290

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