Negative regulation of T _H 17-mediated inflammation by the nuclear receptor REV-ERBβ

Abstract excerpt

<h4>SUMMARY</h4> T H 17 cells play a central role in several human autoimmune diseases. We and others reported the nuclear receptor, REV-ERBα, as a cell-intrinsic repressor of T H 17-mediated pathogenicity. REV-ERBβ, REV-ERBα’s closely related family member, is thought to be functionally redundant to REV-ERBα, which we sought to explore in T H 17-mediated immunity. Our data indicate that deletion of REV-ERBβ e...

Topics

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• Binding Sites
• Cytokine Signaling Pathways and Interactions
• Down-Regulation
• Enhancer Elements, Genetic
• Gene Knockdown Techniques
• Macrophages
• Monoclonal and Polyclonal Antibodies Research
• NF-κB Signaling Pathways

Identifiers and source

Literature Corpus work

068759a2-7455-5691-b8c0-76d9cda4e9f0

DOI

10.64898/2026.01.26.701826