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Article

Estrogen Receptor α Mediates Estrogen’s Immune Protection in Autoimmune Disease

1 Dec 2003

Abstract excerpt

Estrogens are known to influence a variety of autoimmune diseases, but it is not known whether their actions are mediated through classic estrogen receptor alpha (ERalpha). The presence of a functional ER was demonstrated in secondary lymphoid tissues, then ERalpha expression was shown at both the RNA and protein levels in these tissues. Use of ERalpha knockout mice revealed that both the estrogen-induced disease...

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PMID: 14662901
DOI: 10.4049/jimmunol.171.12.6936

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