Article
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.
Nature - 27 Jun 2013
Lam Michael T Y, Cho Han, Lesch Hanna P, Gosselin David, Heinz Sven, Tanaka-Oishi Yumiko, Benner Christopher, Kaikkonen Minna U, Kim Aneeza S, Kosaka Mika, Lee Cindy Y, Watt Andy, Grossman Tamar R, Rosenfeld Michael G, Evans Ronald M, Glass Christopher K
Abstract excerpt
Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response elements in enhancers and promoters of target genes, but the molecular basis for cell-specific programs of...
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