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Article

TERC promotes cellular inflammatory response independent of telomerase

5 Jul 2019

Abstract excerpt

TERC is an RNA component of telomerase. However, TERC is also ubiquitously expressed in most human terminally differentiated cells, which don't have telomerase activity. The function of TERC in these cells is largely unknown. Here, we report that TERC enhances the expression and secretion of inflammatory cytokines by stimulating NK-κB pathway in a telomerase-independent manner. The ectopic expression of TERC in...

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PMID: 31294790
DOI: 10.1093/nar/gkz584

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