Structure–Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders

Abstract excerpt

Autoimmune diseases affect 50 million Americans, predominantly women, and are thought to be one of the top 10 leading causes of death among women in age groups up to 65 years. A central role for T H 17 cells has been highlighted by genome-wide association studies (GWAS) linking genes preferentially expressed in T H 17 cells to several human autoimmune diseases. We and others have reported that the nuclear...

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