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CREMα overexpression decreases IL-2 production, induces a TH17 phenotype and accelerates autoimmunity

20 Feb 2012

Abstract excerpt

Dear Editor, External cytokines produced by cells of the innate immune system induce the differentiation of CD4+ T cells into helper T cell subsets with distinct functions and cytokine profiles. Apart from TH1 and TH2 cells a third subset of helper T cells has been described, which is characterized by increased expression of IL-17A, IL-17F, IL-21 and IL-22 (TH17 cells). TH17 cells are involved in the clearance of...

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PMID: 22355096
DOI: 10.1093/jmcb/mjs004

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