Article

Ameliorative Inhibition of SIRT6 by Imidazole Derivative Triggers Oxidative Stress-Mediated Apoptosis Associated with Nrf2/Keap1 Signaling in NSCLC Cell Lines

2023-08-07

Abstract excerpt

The nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) signaling is the major regulator of redox homeostasis. The imbalance of redox homeostasis causes oxidative stress. Keap1 is the one that regulates Nrf2 by binding to Nrf2. Nrf2/Keap1 signaling is reported to be involved in cancer cell growth and survival. The high level of Nrf2 in cancers is as...

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Literature Corpus work: 06800df4-afcb-5495-bdc0-425e6e2da62f
DOI: 10.20944/preprints202308.0482.v1

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