Article

Integrin α6β4 is downregulated in mutant IDH1 oligodendrogliomas, promotes glioma growth, and associates with a worse outcome in glioma patients

2019-08-15

Abstract excerpt

The integrin α6β4 is a laminin receptor that associates with aggressive behavior in many cancers, though its significance in gliomas has not been established. Mutations in isocitrate dehydrogenase 1 and 2 (IDH mut ) are common in gliomas, especially 1p/19q co-deleted oligodendrogliomas, and correlate with improved patient survival. We sought to determine whether there is a link between integrin β4 and malignant...

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Literature Corpus work: 0661280d-653f-5cd8-ba94-6fb2e98eb90a
DOI: 10.1101/726489

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