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Article

1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas.

Cellular oncology (Dordrecht, Netherlands) - 1 Feb 2021

Zhang Yanyu, Xie Yuan, He Liqun, Tang Jiefu, He Qiyuan, Cao Qingze, Cui Langjun, Guo Wei, Hua Kai, Dimberg Anna, Wang Liang, Zhang Lei

Abstract excerpt

BACKGROUND: Tumor-associated macrophages (TAM)s are critical regulators of glioma progression. As yet, however, TAMs in isocitrate dehydrogenase (IDH) mutated lower-grade gliomas (LGGs) have not been thoroughly investigated. The aim of this study was to determine whether 1p/19q co-deletion status affects the TAM phenotype or its prevalence in IDH mutated LGGs. METHODS: TAMs in IDH mutated LGGs were analyzed using...

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PMID: 32915415
DOI: 10.1007/s13402-020-00561-1
PMCID: PMC12980690

Genes

CD86
TNF

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