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Article

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.

Cancer cell - 11 Apr 2016

Wei Wei, Shin Young Shik, Xue Min, Matsutani Tomoo, Masui Kenta, Yang Huijun, Ikegami Shiro, Gu Yuchao, Herrmann Ken, Johnson Dazy, Ding Xiangming, Hwang Kiwook, Kim Jungwoo, Zhou Jian, Su Yapeng, Li Xinmin, Bonetti Bruno, Chopra Rajesh, James C David, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S, Heath James R, Gini Beatrice

Abstract excerpt

Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy resistance, including in the highly lethal brain cancer glioblastoma (GBM). We performed single-cell phosphoproteomics on a patient-derived in vivo GBM model of mTOR kinase inhibitor resistance and coupled it to an analytical approach for detecting changes in signaling coordination. Alterations in the protein signaling...

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Identifiers

PMID: 27070703
DOI: 10.1016/j.ccell.2016.03.012
PMCID: PMC4831071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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