Article

Intratumoral MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with selective CREB signaling and specific functional gene signatures

2018-04-20

Abstract excerpt

Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due to intratumoral heterogeneity. Heterogeneity arises due to the genetic and epigenetic variation of tumor cells in response to microenvironmental interactions and cytotoxic therapy. We explored specific signaling pathway activation in glioblastoma (GBM) by investigating the intratumoral...

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Literature Corpus work: 2d5f5615-7144-50d3-a62a-7160159f7b04
DOI: 10.1101/305052

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