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Article

Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis

27 Jun 2013

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) genomes feature recurrent genetic alterations that dysregulate core intracellular signaling pathways, including the G1/S cell cycle checkpoint and the MAPK and PI3K effector arms of receptor tyrosine kinase (RTK) signaling. Elucidation of the phenotypic consequences of activated RTK effectors is required for the design of effective therapeutic and diagnostic strategies. METHODS:...

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PMID: 23814263
DOI: 10.1093/neuonc/not084

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