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Article

Mutations in the FMN domain modulate MCD spectra of the heme site in the oxygenase domain of inducible nitric oxide synthase.

Journal of the American Chemical Society - 27 May 2009

Sempombe Joseph, Elmore Bradley O, Sun Xi, Dupont Andrea, Ghosh Dipak K, Guillemette J Guy, Kirk Martin L, Feng Changjian

Abstract excerpt

The nitric oxide synthase (NOS) output state for NO production is a complex of the flavin mononucleotide (FMN)-binding domain and the heme domain, and thereby it facilitates the interdomain electron transfer from the FMN to the catalytic heme site. Emerging evidence suggests that interdomain FMN-heme interactions are important in the formation of the output state because they guide the docking of the FMN domain...

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Identifiers

PMID: 19405537
DOI: 10.1021/ja902141v
PMCID: PMC2754207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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