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Article

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B.

Toxins - 15 Aug 2016

Chen Shuyi, Wang Haiying, Gu Huawei, Sun Chunli, Li Shan, Feng Hanping, Wang Jufang

Abstract excerpt

Clostridium difficile toxin A (TcdA) and toxin B (TcdB) are the major virulence factors involved in C. difficile-associated diarrhea and pseudomembranous colitis. TcdA and TcdB both contain at least four distinct domains: the glucosyltransferase domain, cysteine protease domain, receptor binding domain, and translocation domain. Few studies have investigated the translocation domain and its mechanism of action....

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Identifiers

PMID: 27537911
DOI: 10.3390/toxins8080241
PMCID: PMC4999857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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