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Article

Molecular mechanisms of PINK1-related neurodegeneration.

Current neurology and neuroscience reports - 1 Jun 2011

Pogson Joe H, Ivatt Rachael M, Whitworth Alexander J

Abstract excerpt

PINK1 is a mitochondrially targeted kinase that has been linked to a rare monogenic form of Parkinson's disease (PD), a common neurodegenerative disease characterized by the degeneration of selected dopaminergic neurons. Intensive research using many model systems has clearly established a fundamental role for PINK1 in preventing mitochondrial dysfunction-a key mechanism long thought to play a central role in PD...

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Source

Identifiers

PMID: 21331528
DOI: 10.1007/s11910-011-0187-x

Genes

PINK1

Provenance

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