Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease

4 Nov 2021

Abstract excerpt

The progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying Parkinson's disease (PD), while the mechanism of susceptibility of this specific neuronal population is largely unclear. Disturbances in mitochondrial function have been recognized as one of the main pathways in sporadic PD since the finding of respiratory chain impairment in animal models of PD....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34831247
DOI: 10.3390/cells10113022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s DiseasePMID 34831247Read ↗

The mitochondrial kinase <scp>PINK</scp>1: functions beyond mitophagySemantic proximity Read ↗

Mitophagy in Parkinson’s Disease: From Pathogenesis to TreatmentSemantic proximity Read ↗

Uncovering the roles of PINK1 and parkin in mitophagy.Semantic proximity Read ↗

Mitophagy and Parkinson's disease: The PINK1–parkin linkSemantic proximity Read ↗

Genetic mutations and functions of PINK1.Semantic proximity Read ↗

Regulation of PINK1-Parkin-mediated mitophagySemantic proximity Read ↗

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?Semantic proximity Read ↗

Mechanisms Associated with PINK1 Mutations in Parkinson's DiseaseSemantic proximity Read ↗

PINK1/PARKIN signalling in neurodegeneration and neuroinflammationSemantic proximity Read ↗

PINK1 function in health and disease.Semantic proximity Read ↗

Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s DiseaseSemantic proximity Read ↗

Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.