Article
Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1.
Journal of neuropathology and experimental neurology - 1 Sept 2009
Yang Yufeng, Lu Bingwei
Abstract excerpt
The etiology of Parkinson disease (PD) has been assumed to be a complex combination of environmental factors, intrinsic cellular metabolic properties, and susceptible genetic alleles. The primary obstacles to the development of a neuroprotective therapy in PD include uncertainties with regard to the precise cause(s) of neuronal dysfunction and what to target. The discoveries of Mendelian genes associated with...
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