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Article

Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2008

Wang Qianwen, Donthi Rajakumar V, Wang Jianxun, Lange Alex J, Watson Lewis J, Jones Steven P, Epstein Paul N

Abstract excerpt

During ischemia and heart failure, there is an increase in cardiac glycolysis. To understand if this is beneficial or detrimental to the heart, we chronically elevated glycolysis by cardiac-specific overexpression of phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-...

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Identifiers

PMID: 18456722
DOI: 10.1152/ajpheart.91501.2007
PMCID: PMC4239994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18456722-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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