Article

Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

2020-11-30

Abstract excerpt

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia, but the mechanism of predisposition is unclear. As Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular context of preleukemic initiation and leukemic progression using gene editing in human disomic and trisomic fetal liver hematopoietic cells and xenotransplantation. GATA1 mutation...

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Literature Corpus work: 05c26cf9-d308-592d-9d1b-dca0219c2ca3
DOI: 10.1101/2020.11.29.402800

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