Leukemogenesis in infants and young children with trisomy 21.

doi:10.1182/hematology.2022000395

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Article

Leukemogenesis in infants and young children with trisomy 21.

Hematology. American Society of Hematology. Education Program - 9 Dec 2022

Roberts Irene

Abstract excerpt

Children with Down syndrome (DS) have a greater than 100-fold increased risk of developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of acute lymphoblastic leukemia (ALL) before their fifth birthday. ML-DS originates in utero and typically presents with a self-limiting, neonatal leukemic syndrome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between...

Topics

Infant
Infant, Newborn
Child
Humans
Child, Preschool
Down Syndrome
Leukemoid Reaction
GATA1 Transcription Factor
Leukemia, Myeloid, Acute
Mutation

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Identifiers

PMID: 36485097
DOI: 10.1182/hematology.2022000395
PMCID: PMC9820574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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