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Article

Leukemogenesis in infants and young children with trisomy 21.

Hematology. American Society of Hematology. Education Program - 9 Dec 2022

Roberts Irene

Abstract excerpt

Children with Down syndrome (DS) have a greater than 100-fold increased risk of developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of acute lymphoblastic leukemia (ALL) before their fifth birthday. ML-DS originates in utero and typically presents with a self-limiting, neonatal leukemic syndrome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between...

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Identifiers

PMID: 36485097
DOI: 10.1182/hematology.2022000395
PMCID: PMC9820574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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