Mapping the cellular origin and early evolution of leukemia in Down syndrome.

doi:10.1126/science.abf6202

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Article

Mapping the cellular origin and early evolution of leukemia in Down syndrome.

Science (New York, N.Y.) - 9 Jul 2021

Wagenblast Elvin, Araújo Joana, Gan Olga I, Cutting Sarah K, Murison Alex, Krivdova Gabriela, Azkanaz Maria, McLeod Jessica L, Smith Sabrina A, Gratton Blaise A, Marhon Sajid A, Gabra Martino, Medeiros Jessie J F, Manteghi Sanaz, Chen Jian, Chan-Seng-Yue Michelle, Garcia-Prat Laura, Salmena Leonardo, De Carvalho Daniel D, Abelson Sagi, Abdelhaleem Mohamed, Chong Karen, Roifman Maian, Shannon Patrick, Wang Jean C Y, Hitzler Johann K, Chitayat David, Dick John E, Lechman Eric R

Abstract excerpt

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia, but the mechanism of predisposition is unclear. Because Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular and developmental context of preleukemic initiation and leukemic progression using gene editing in human disomic and trisomic fetal hematopoietic cells and...

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PMID: 34244384
DOI: 10.1126/science.abf6202

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