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Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

31 Jul 2020

Abstract excerpt

Children show a higher incidence of leukemia compared to young adolescents, yet their cells have less age-related (oncogenic) somatic mutations. Newborns with Down syndrome have an even higher risk of developing leukemia, which is thought to be driven by mutations that accumulate during fetal development. To characterize mutation accumulation in individual stem and progenitor cells of Down syndrome and...

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PMID: 32737409
DOI: 10.1038/s41598-020-69822-1

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