Article
Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.
Cell reports - 10 May 2016
Banno Kimihiko, Omori Sayaka, Hirata Katsuya, Nawa Nobutoshi, Nakagawa Natsuki, Nishimura Ken, Ohtaka Manami, Nakanishi Mahito, Sakuma Tetsushi, Yamamoto Takashi, Toki Tsutomu, Ito Etsuro, Yamamoto Toshiyuki, Kokubu Chikara, Takeda Junji, Taniguchi Hidetoshi, Arahori Hitomi, Wada Kazuko, Kitabatake Yasuji, Ozono Keiichi
Abstract excerpt
Chromosomal aneuploidy and specific gene mutations are recognized early hallmarks of many oncogenic processes. However, the net effect of these abnormalities has generally not been explored. We focused on transient myeloproliferative disorder (TMD) in Down syndrome, which is characteristically associated with somatic mutations in GATA1. To better understand functional interplay between trisomy 21 and GATA1...
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