Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

16 Nov 2018

Abstract excerpt

INTRODUCTION: Recent studies on CD19-specific chimeric antigen receptor (CAR)-modified T cells (CARTs) have demonstrated unprecedented successes in treating refractory and relapsed B cell malignancies. The key to the latest CART therapy advances can be attributed to the improved costimulatory signals in the CAR design. METHODS: Here, we established several novel CARs by incorporating T cell signaling domains of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30444200
DOI: 10.2174/1566523218666181116093857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα SignalingPMID 30444200Read ↗

Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effectsSemantic proximity Read ↗

Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T CellsSemantic proximity Read ↗

Chimeric antigen receptor-modified T cells strike backSemantic proximity Read ↗

A CHIMERIC RECEPTOR ENABLING ANTIBODY-GUIDED RETARGETING OF CAR T- CELLSSemantic proximity Read ↗

Development of a Gene Editing Platform to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 LocusSemantic proximity Read ↗

Chimeric Antigen Receptors: A Paradigm Shift in ImmunotherapySemantic proximity Read ↗

Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicitiesSemantic proximity Read ↗

CAR therapy: the CD19 paradigmSemantic proximity Read ↗

Engineering better chimeric antigen receptor T cellsSemantic proximity Read ↗

Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine ReceptorsSemantic proximity Read ↗

CAR-T design: Elements and their synergistic functionSemantic proximity Read ↗

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular ImmunotherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.