Article

Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer’s Disease

2022-03-03

Abstract excerpt

Alzheimer’s disease (AD) risk increases exponentially with age and is associated with multiple molecular hallmarks of aging, one of which is epigenetic alterations. Epigenetic age predictors based on 5’ cytosine methylation (DNAm) have previously suggested that biological age acceleration may occur in AD brain tissue. To further investigate brain epigenetic aging in AD, we generated a novel age predictor termed PC...

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Literature Corpus work: 05b57d28-7503-5c97-8547-2eea3e55f989
DOI: 10.1101/2022.02.28.481849

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