Article
The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes.
Neurobiology of disease - 1 Sept 2021
Grodstein Francine, Lemos Bernardo, Yu Lei, Klein Hans-Ulrich, Iatrou Artemis, Buchman Aron S, Shireby Gemma L, Mill Jonathan, Schneider Julie A, De Jager Philip L, Bennett David A
Abstract excerpt
Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date. Yet, limited research has considered epigenetic clocks calculated in brain tissue. We used DNA methylation states in dorsolateral prefrontal cortex specimens from 721 older participants of the Religious Orders Study and...
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