Back to search

Article

Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors

2023-02-22

Abstract excerpt

<title>Abstract</title> <p>Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
12577202-1d63-5405-a81e-e35c72f36e0c
DOI
10.21203/rs.3.rs-2542996/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumorsDOI 10.21203/rs.3.rs-2542996/v1
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.Semantic proximity
Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial designSemantic proximity
The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies.Semantic proximity
A living pediatric brain tumor atlas reveals histomolecular diversity and therapeutic vulnerabilities for precision neuro-oncologySemantic proximity
Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)Semantic proximity
PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models.Semantic proximity
PCAT: An integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft modelsSemantic proximity
Functional Precision Medicine Enhances Clinical Outcomes of Relapsed/Refractory Pediatric and Adolescent Cancer PatientsSemantic proximity
Future Match Making: When Pediatric Oncology Meets Organoid TechnologySemantic proximity
Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug ResponseSemantic proximity
Data-driven approaches to advance research and clinical care for pediatric cancer.Semantic proximity
An update on genomic-guided therapies for pediatric solid tumors.Semantic proximity
Select a neighboring publication to make it the new centre.