Article

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

2019-12-19

Abstract excerpt

Murine xenografts of pediatric leukemia are known to accurately recapitulate genomic aberrations. How this translates to the functional capacity of the proteome is unknown. Here, we studied global protein abundance, phosphorylation, and proteolytic processing in 11 pediatric B- and T-cell acute lymphoblastic leukemia patients and 19 corresponding xenografts. Protein level differences that stratified pediatric dise...

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Literature Corpus work: 8ceefa9c-f240-540e-ae69-d97f0b0cee4b
DOI: 10.1101/2019.12.18.880401

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