Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

1 Nov 2019

Abstract excerpt

Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (<3 years of age). It remains plagued with extremely poor treatment outcomes (<40% cure rates), mostly due to primary chemotherapy refractory disease and/or early relapse. Recurrent and mutually exclusive chimeric fusion oncogenes have been detected in 60% to 70% of cases and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Lymphocytic Leukemia Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31698461
DOI: 10.1182/bloodadvances.2019030981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilitiesPMID 31698461Read ↗

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformationSemantic proximity Read ↗

Molecular Biology of Childhood LeukemiaSemantic proximity Read ↗

Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98 -rearranged leukemiaSemantic proximity Read ↗

Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.Semantic proximity Read ↗

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.Semantic proximity Read ↗

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft modelsSemantic proximity Read ↗

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape StudySemantic proximity Read ↗

Mechanistic insights and potential therapeutic approaches for NUP98 -rearranged hematologic malignanciesSemantic proximity Read ↗

NUP98-HBO1–fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesisSemantic proximity Read ↗

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsSemantic proximity Read ↗

Fusion oncoproteins and cooperating mutations define disease phenotypes in<i>NUP98</i>-rearranged leukemiaSemantic proximity Read ↗

Clinicogenetic characteristics and outcomes of children with NUP98-rearranged acute myeloid leukaemia: A single-centre cohort study of 32 cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.