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Identification of Downregulated MECR Gene in Parkinson’s Disease Through Integrated Transcriptomic Analysis and Validation

10 Jan 2025

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (α-syn) aggregation. Lipid metabolism dysfunction may contribute to PD progression. This study aims to identify lipid metabolism-related genes (LMGs) associated with PD using an integrative transcriptomic analysis of microarray and single-cell RNA sequencing (scRNA-seq) datasets from patients...

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PMID: 39859268
DOI: 10.3390/ijms26020550

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