Article

Lysosomal Enhancement Prevents Infection with PrP <sup>Sc</sup> , α-Synuclein & Tau Prions

2025-06-25

Abstract excerpt

Prion diseases are fatal neurodegenerative diseases of humans and other mammals with no current treatment options. Here, we describe the characterization of a novel anti-prion compound, elacridar (GW120918), which has sub-micromolar activity in assays of prion infection, propagation and toxicity. Elacridar acts at an early step in the prion infection process, enhancing degradation of newly formed PrP Sc . The lys...

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Identifiers and source

Literature Corpus work: 24b104c6-aca3-519f-a8c8-730dbfe45c45
DOI: 10.1101/2025.06.24.661349

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