Article

Nonlinear ridge regression improves cell-type-specific differential expression analysis

2020-06-19

Abstract excerpt

<h4>Background</h4> Epigenome-wide association studies (EWAS) and differential gene expression analyses are generally performed on tissue samples, which consist of multiple cell types. Cell-type-specific effects of a trait, such as disease, on the omics expression are of interest but difficult or costly to measure experimentally. By measuring omics data for the bulk tissue, cell type composition of a sample can b...

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Literature Corpus work: 05821f70-6a13-5f77-8b7d-768612242c34
DOI: 10.1101/2020.06.18.158758

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