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Article

Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.

The international journal of neuropsychopharmacology - 1 Oct 2025

Shoji Hirotaka, Hagihara Hideo, Graef Isabella A, Crabtree Gerald R, Huang Freesia L, Frankland Paul W, Miyakawa Tsuyoshi

Abstract excerpt

BACKGROUND: The hippocampal dentate gyrus (DG) is a critical region that contributes to recent and remote memory. Granule cells within this region, in which adult neurogenesis occurs, undergo dynamic and reversible maturation via genetic and environmental factors during adulthood. A pseudo-immature state of DG granule cells, called immature DG (iDG), has been observed in the adult mice of certain mutant strains,...

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Identifiers

PMID: 40847814
DOI: 10.1093/ijnp/pyaf062
PMCID: PMC12553137

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