Article
From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders.
Cerebral cortex (New York, N.Y. : 1991) - 17 Oct 2016
Hartung Henrike, Cichon Nicole, De Feo Vito, Riemann Stephanie, Schildt Sandra, Lindemann Christoph, Mulert Christoph, Gogos Joseph A, Hanganu-Opatz Ileana L
Abstract excerpt
Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part from abnormal communication within hippocampal-prefrontal circuits. While it has been hypothesized that this network dysfunction arises during development, long before the first clinical symptoms, experimental evidence is still missing. Here, we show that pre-juvenile mice mimicking genetic and environmental risk factors...
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